The rest were designated as the control group, and risk factors for the fatal recurrence group were analyzed. Recurrence after curative resection for hepatocellular carcinoma (HCC) is a major cause of death from this disease. zyx zyxwvuts Wound Recurrence After Resection of Hepatocellular Carcinoma Eric Kofi, * Vincent Moutavdiev, * Alain Sauvanet, * Roger Noun, * Jean Fvangois Fleou, t and Jacques Belghiti * zyxwvu Cutaneous metastases arising along the exit site malignant seeding may occur, and the authors of an abdominal drain in one patient and within the recommend the observance of special care dur- operative . In cases of hepatocellular carcinoma (HCC) with microvascular invasion (MVI), tumor recurrence after hepatectomy was shown to have unique features and recurrence patterns. Cumulative recurrence rate after resection of HCC. The patterns of late recurrence suggested surveillance for recurrence after 2 years of surgery should be targeted to the liver. This study aimed to develop a machine learning prognostic model to identify high-risk patients after surgical resection and to review importance of variables in . it demonstrated a significant prolongation of rFS and reduced extrahepatic recurrence in Huaier group. Hepatocellular carcinoma (HCC) is currently the fifth most common cancer globally, accounting for the third highest cancer-related deaths (1). Very little is known about the prognosis of HCC that recurs after resection and the outcomes associated with treatments applied to recurrent tumors. The 2nd patient, operated on because of a solitary HCC of 2 cm without capsule and moderately differentiated, developed a solitary tumor recurrence and was enlisted 18 months after resection. It is therefore of paramount importance to select patients for suitable treatment due to the high risk of associated As such, identifying and reducing risk factors associated with recurrence is critical to improving long-term oncological outcomes after HCC resection. The outcomes of HCC associated with PVTT remain unsatisfactory because of a high incidence of tumor recurrence even after curative resection. aggressive treatment of hcc recurrence after liver resection is associated with increased survival rates. hepatic resection is a well-accepted therapy for hepatocellular carcinoma (hcc), but many patients develop a cancer recurrence, which is the main cause of death in long-term evaluations.1-3prevention and therapy for recurrence could further improve the data of survival and support the value of surgery when compared to non surgical procedures such … Estimated annual recurrence rate following curative-intent resection for HCC within and beyond the BCLC criteria during postoperative years 1, 2, 3, 4, 5, and 6. The aim of this study was to develop evolutionary learning-derived prediction models with interpretability using both clinical and radiomic features to predict early recurrence of HCC after . Design and results A . Postoperative surveillance improved the chance of potentially curative treatments . Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) indicates a poor prognosis. There is no consensus or guideline about the best treatment option for such recurrent HCC (rHCC). Thus, TACE has been frequently performed to control recurrent HCC after resection, if there is no evidence of extra-hepatic metastasis or vessel invasion [9-11]. Time and the type of presentation of the recurrence are the best determinants of the prognosis. for Hcc after curative liver resection. Unlabelled: Liver resection (LR) for hepatocellular carcinoma (HCC) as the first-line treatment in transplantable patients followed by "salvage transplantation" (ST) in case of recurrence is an . The patients were monitored by serum testing (including AFP, ALT, AST, DDR1) every month and abdomen ultrasonography every 2 months after the surgery. The recurrence rate after primary resection for hepatocellular carcinoma (HCC) has been reported to be up to 80%. Liver resection is a mainstay of the treatment algorithm for patients with preserved liver function and early-stage hepatocellular carcinoma, but the risk of recurrence is up to 70% 1 due to the appearance of previously undetected metastatic disease as well as de novo tumours. 18 cycles adjuvant treatment with TQB2450 Plus anlotinib can improve one-year recurrence free survival (RFS) rate of HCC patients after R0 surgical resection. The patterns of late recurrence suggested surveillance for recurrence after 2 years of surgery should be targeted to the liver. Methods: We retrospectively evaluated preoperative clinical variables and circulating (plasma) biomarkers of angiogenesis and inflammation in a cohort of HCC patients who underwent liver . We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Trametes robinophila Murr (Huaier granule) to address this unmet need. Recurrence following resection of HCC. Abstract: Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. Angiogenesis and inflammation are hallmarks of HCC progression and therapeutic targets. [ 100]. it demonstrated a significant prolongation of rFS and reduced extrahepatic recurrence in Huaier group. However, the 5-year recurrence and survival rates after resection for HCC, which are 60% and 50%, respectively, remain unsatisfactory [10, 11]. Background and Aims: Current prediction models for early recurrence of hepatocellular carcinoma (HCC) after surgical resection remain unsatisfactory. Methods Factors of primary curative resection are available and potential in the prognosis of follow-up treatment. Tumor recurrence remains the major cause of death after curative resection for hepatocellular carcinoma (HCC). Hence, a clinicopathologic study was conducted to clarify whether different risk factors were associated for Hcc after curative liver resection. 14-16 Although there is no consensus about the exact timing of early recurrence among patients with ICC, using a cutoff of 2 years for ICC may be problematic because many patients with ICC have . Objective: To explore the prognostic value of the postsurgical half-life (HL) of serum alpha-fetoprotein (AFP). impact of direct-acting antivirals on HCC recurrence is still a controversial topic. Background: There is still a paucity of early surrogate indicators of clinical endpoints after liver resection of hepatocellular carcinoma (HCC). Very little is known about the prognosis of HCC that recurs after resection and the outcomes associated with treatments applied to recurrent tumors. On the basis of the reported survival benefit of TACE, TACE has been widely used for patients with Barcelona Clinic Liver Cancer (BCLC) intermediate stage HCC [10, 12, 13]. People have tried a number of approaches to prevent recurrence, however, only a few of them were designed as Late recurrence after HCC resection was associated with sex, cirrhosis, and several aggressive tumor characteristics of the initial HCC. rate, the 5-year recurrence rate after curative resection was 38 %[1] and 61.5 %[2], the 5-year disease-free survival was 16 %[3] or [38.6 % 4] after curative resection of HCC, and the recurrence resulted in most deaths after resection[5]. The detection of HCC during its early stage of development is a crucial factor that affects the prognosis of HCC patients . Background: The NIVOLVE trial was designed to assess the efficacy and safety of nivolumab as an adjuvant therapy for HCC, and to identify biomarkers predictive of recurrence in patients after SR or RFA (Registration # UMIN 000026648).Methods: The trial involved 11 sites and was conducted in patients with HCC who showed a complete response after SR (n = 33) or RFA (n = 22) (ITT). 14-16 Although there is no consensus about the exact timing of early recurrence among patients with ICC, using a cutoff of 2 years for ICC may be problematic because many patients with ICC have . Sorafenib might be an effective option for preventing HCC recurrence after resection. We herein report a case of recurrent HCC detected at 20 weeks of pregnancy, which subsequently prompted hepatic resection after abortion. Treatment strategies for cancers detected during pregnancy have been controversial. Hence, the evaluation of predictive factors of overall survival after surgical . Liver resection is the treatment modality of choice for resectable HCCs with adequate liver function in the absence of portal hypertension (1), but actuarial recurrence rates remain as high as 70% at 5 years post-resection (2). The recurrence rate after primary resection for hepatocellular carcinoma (HCC) has been reported to be up to 80%. In clinical practice, it is difficult to predict which individuals would have tumor recurrence after curative resection for early-stage HCC, such as BCLC 0+A-stage patients . Early recurrence is considered as originating from the initial tumour, whereas late recurrence is thought to result from de novo . Background: The NIVOLVE trial was designed to assess the efficacy and safety of nivolumab as an adjuvant therapy for HCC, and to identify biomarkers predictive of recurrence in patients after SR or RFA (Registration # UMIN 000026648).Methods: The trial involved 11 sites and was conducted in patients with HCC who showed a complete response after SR (n = 33) or RFA (n = 22) (ITT). [ 7-12] several authors reported an increased survival after repeated liver resection. Background . Intrahepatic HCC recurrence within 2 years after surgical resection is usually classified as early recurrence and that occurring beyond 2 years after surgery is characterised as late recurrence [ 14, 15, 17, 18 ]. Liver resection is a mainstay of the treatment algorithm for patients with preserved liver function and early-stage hepatocellular carcinoma, but the risk of recurrence is up to 70% 1 due to the appearance of previously undetected metastatic disease as well as de novo tumours. Neoadjuvant immunotherapy Libtayo administered before surgical resection led to tumor necrosis in about one-third of patients with hepatocellular carcinoma, according to data published in The . Therefore, we aimed to compare the different effects of NtAs and NsAs on HCC recurrence and overall survival It recurs in 50-80% of patients following resection, with the majority of recurrences developing within 2 years. A Study to Evaluate Camrelizumab Plus Rivoceranib (Apatinib) as Adjuvant Therapy in Patients With Hepatocellular Carcinoma (HCC) at High Risk of Recurrence After Curative Resection or Ablation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Introduction. Methods: The analysis was based on cohorts of 225 (exploration set) and 117 (validation set) treatment-naïve HCC patients undergoing . We conducted a case-control study to investigate it. Surgery is considered the only curative option for selected patients with HCC recurrence following LT. Traditionally, the preference is given to the open approach. recurrence after resection of HCC, but none has spe-cifically examined whether there is a difference in the risk factors linked to early and late recurrences. However, the 5-year recurrence and survival rates after resection for HCC, which are 60% and 50%, respectively, remain unsatisfactory [10, 11]. Hepatocellular carcinoma (HCC) ranks as the sixth most common malignancy worldwide [].Although approximately 80% of the patients suffer from relapse within 5 years after radical treatments for primary HCC, those with recurrences at the Barcelona Clinic Liver Cancer (BCLC) 0/A stage can benefit from resection or ablation [2, 3].Re-resection is often unsuitable for HCC patients with recurrences . Background/aims: The prognostic impact of serum alpha-fetoprotein (AFP) on patients with hepatocellular carcinoma (HCC) undergoing curative resection remains unclear. The inclusion criteria of the fatal recurrence group were the patients who had diffuse intra-hepatic recurrence or multiple systemic recurrence within 6 mo after curative surgical resection of HCC. The predominant cause of tumor recurrence is metachronous carcinogenesis, as the precursor condition (cirrhosis) persists after surgery 74. Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, and surgical resection offers an opportunity for cure in patients fortunate enough to have tumors amenable to resection. There is no consensus or guideline about the best treatment option for such recurrent HCC (rHCC). When treated with a curative procedure, the survival of the patients who recurred is quite satisfying. HBV-related hepatocellular carcinoma after surgical resection Li Weng1†, Juan Du1†, Qinghui Zhou1, Binbin Cheng1, Jun Li1, Denghai Zhang2 and Changquan Ling1,3* Abstract Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. The reported . currence after R0 resection in primary hepatocellular carcinoma SONGPENG LI, LIQUN WU Abstract Objectives: To investigate the impact of serum α-fetoprotein (AFP) levels on survival and early recurrence after R0 resection in primary hepatocellular carcinoma (HCC). However, due to the small number of included studies and large heterogeneity among them, the level of evidence for this result was low, and more high-quality studies need to be analyzed . Improved long-term survival outcomes were achieved by early detecting tumor recurrence and with repeat liver resection with curative intent. For patients with recurrent HCC with MVI after curative resection, the therapeutic effect of RF/re-resection was not significantly different from that of TACE. Introduction. By univariate analysis, following resection, vascular invasion, advanced stage, multiple tumors, and lack of a capsule were predictive of survival; cirrhosis, HBV, age, tumor size, number, and grade were not. lihood of HCC recurrence, with most solely extracting engi-neered features from tumor; however, peritumoral area harbors highly invasive tumor cells. consensus for the management of recurrence and metastasis after HCC resection. Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide, and more than 800 thousand new cases were diagnosed in 2018 alone ().Curative liver resection remains as the first line therapy for HCC, however, tumor recurrence occurred in approximately 70% patients after curative treatment or transplantation, resulted in 5-year survival rates ranging from 40 . In the future, more well-designed, large-scale . It is still unclear whether NtAs and NsAs have different effects on HCC recurrence rates in patients with HBV- related HCC after curative resection. Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading global cause of cancer-related death, with China accounting for over half of the number of cases and deaths [].The high recurrence rate after curative hepatic resection for HCC, especially within the first 2 years after resection, remains a major challenge for long-term survival [2,3,4]. Although the management and outcomes of patients with HCC and PVTT have greatly improved over the years, surgical resection remains an option to achieve a potential cure of HCC in well-selected patients. However, the results of this meta-analysis need to be interpreted with caution because sorafenib might only be effective in patients with certain risk factors or those with particular activated signaling pathways. Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading global cause of cancer-related death, with China accounting for over half of the number of cases and deaths [].The high recurrence rate after curative hepatic resection for HCC, especially within the first 2 years after resection, remains a major challenge for long-term survival [2,3,4]. The annual recurrence rate of HCC after surgical resection is ≥10% and reaches 70-80% after 5 years [ 2, 3, 4, 5 ]. 416. Objective: There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). Summary Background Data 1 Early-stage HCC can Our aim was to assess the prognostic significance of primary curative resection factors in recurrent HCC patients undergoing radiofrequency ablation therapy (RFA . A 36-year-old woman underwent laparoscopic partial hepatectomy for HCC (20 mm in diameter) in segment 5 of .
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